Myeloid STAT3 Inhibits T Cell-Mediated Hepatitis by Regulating T Helper 1 Cytokine and Interleukin-17 Production
نویسندگان
چکیده
منابع مشابه
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells.
Interleukin-17 (IL-17)-producing helper T (TH) cells, named as TH(IL-17), TH17, or inflammatory TH (THi), have been recently identified as a novel effector lineage. However, how cytokine signals mediate THi differentiation is unclear. We found that IL-6 functioned to up-regulate IL-23R and that IL-23 synergized with IL-6 in promoting THi generation. STAT3, activated by both IL-6 and IL-23, play...
متن کاملAutoimmune regulator‑overexpressing dendritic cells induce T helper 1 and T helper 17 cells by upregulating cytokine expression.
The autoimmune regulator (Aire) protein is a transcriptional activator that is essential in central immune tolerance, as it regulates the ectopic expression of many tissue‑restricted antigens in medullary thymic epithelial cells. Aire expression has also been described in hematopoietic cells, such as monocytes/macrophages and dendritic cells (DCs), in the peripheral immune system. However, the ...
متن کاملSpontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3.
Mycosis fungoides is a low-grade cutaneous T-cell lymphoma (CTCL) of unknown etiology. In advanced stages of CTCL, a shift in cytokine profile from T(H)1 to T(H)2 is observed, which coincides with eosinophilia, high levels of immunoglobulin E, and increased susceptibility to bacterial infections. It is, however, unknown why T(H)2 cytokines predominate in advanced CTCL, and the cellular source o...
متن کاملthe roles of t helper 1, t helper 17 and regulatory t cells in the pathogenesis of sarcoidosis
sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluid...
متن کاملGhrelin Inhibits the Differentiation of T Helper 17 Cells through mTOR/STAT3 Signaling Pathway
Enhanced activity of interleukin 17 (IL-17) producing T helper 17 (Th17) cells plays an important role in autoimmune and inflammatory diseases. Significant loss of body weight and appetite is associated with chronic inflammation and immune activation, suggesting the cross talk between immune and neuroendocrine systems. Ghrelin has been shown to regulate the organism immune function. However, th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Gastroenterology
سال: 2009
ISSN: 0016-5085
DOI: 10.1053/j.gastro.2009.08.004